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doi: 10.6026/973206300200765 88

(1996) first demonstrated that TNF- induces insulin resistance by promoting serine phosphorylation of insulin receptor substrate 1(IRS-1), thereby inhibiting the tyrosine kinase activity of the insulin receptor ( 3.3 The positive feedback loop of hyperandrogenemia Studies have demonstrated that LPS can not only indirectly contribute to hyperandrogenemia by inducing insulin resistance ( 3.4 Adipose tissue dysfunction and metabolic derangements The translocation of LPS into circulation due to intestinal barrier dysfunction disrupts adipose metabolic homeostasis through multiple mechanisms

[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Bratkowski M., Xie T., Thayer D.A., Lad S., Mathur P., Yang Y.-S., Danko G., Burdett T.C., Danao J., Cantor A., et al

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